Introduction
Chemical genomics is a growing field aimed at identifying drug and compound targets to alter protein function, with potential to improve genetic diseases. Forward chemical genomics starts by creating active compounds such as drugs or small molecule inhibitors, and then identifying its targets in a screening assay [1]. Meanwhile in reverse chemical genomics, a target protein is already found and varying chemical compounds are added to a screening to view effects on functionality. Resources such as Pubchem allow for the filtering of data sets and publications to identify compounds of interest for chemical genomics study.
results
Example of workflow of completing a chemical genomics process [2]
Conclusion
At the time of this page being created (April 2024), there are no chemical libraries for COL3A1. However as a future experiment, I would be very interested in a high-throughput chemical screening of mutated vEDS tissue for drug targets. I would like to use aortic tissue from a male COL3A1 mutant zebrafish to do this. The screening would potentially be focused on finding drug targets to improve collagen tensile strength to avoid aortic rupturing.
References
[1] Zheng XFS, Chan T-F. Chemical Genomics: A Systematic Approach in Biological Research and Drug Discovery. Current Issues in Molecular Biology. 2002; 4(2):33-43. https://doi.org/10.21775/cimb.004.033
[2] Image from Underhaug, Jarl & Aubi, Oscar & Martínez, Aurora. (2013). Phenylalanine Hydroxylase Misfolding and Pharmacological Chaperones. Current topics in medicinal chemistry. 12. 10.2174/15680266112129990077.
Image created in Biorender
[2] Image from Underhaug, Jarl & Aubi, Oscar & Martínez, Aurora. (2013). Phenylalanine Hydroxylase Misfolding and Pharmacological Chaperones. Current topics in medicinal chemistry. 12. 10.2174/15680266112129990077.
Image created in Biorender
This web page was produced as an assignment for Genetics 564, a capstone course at UW-Madison