Introduction
Gene Ontology is useful for characterizing a protein's overall function and role [1]. A GO term matches what a gene's product is with an annotation that describes its functionality on a biological, molecular, and cellular level [2]. The specific GO annotation will always contain the gene product, GO term, references, and evidence from prior data and/or experiments.
results
Conclusion
The gene ontology for COL3A1 is centered around collagen and the extracellular matrix, which is expected due to the gene's role in collagen synthesis. COL3A1 is vital for tensile strength and elasticity of collagen. Collagen is the most abundant protein in the extracellular matrix, and type 3 collagen is found in large bundles of fibrils [3].
References
[1] Thomas PD. The Gene Ontology and the Meaning of Biological Function. Methods Mol Biol. 2017;1446:15-24. doi:10.1007/978-1-4939-3743-1_2
[2] Gene ontology overview. (n.d.)., from http://geneontology.org/docs/ontology-documentation/
[3] Zhang, W., Liu, Y. & Zhang, H. Extracellular matrix: an important regulator of cell functions and skeletal muscle development. Cell Biosci 11, 65 (2021). https://doi.org/10.1186/s13578-021-00579-4
[2] Gene ontology overview. (n.d.)., from http://geneontology.org/docs/ontology-documentation/
[3] Zhang, W., Liu, Y. & Zhang, H. Extracellular matrix: an important regulator of cell functions and skeletal muscle development. Cell Biosci 11, 65 (2021). https://doi.org/10.1186/s13578-021-00579-4
This web page was produced as an assignment for Genetics 564, a capstone course at UW-Madison